Article
Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.
Oncotarget - 8 Nov 2016
Dimitriou Marios, Woll Petter S, Mortera-Blanco Teresa, Karimi Mohsen, Wedge David C, Doolittle Helen, Douagi Iyadh, Papaemmanuil Elli, Jacobsen Sten Eirik W, Hellström-Lindberg Eva
Abstract excerpt
The stem and progenitor cell compartments in low- and intermediate-risk myelodysplastic syndromes (MDS) have recently been described, and shown to be highly conserved when compared to those in acute myeloid leukemia (AML). Much less is known about the characteristics of the hematopoietic hierarchy of subgroups of MDS with a high risk of transforming to AML. Immunophenotypic analysis of immature stem and...
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