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Article

TLR4-dependent immune response promotes radiation-induced liver disease by changing the liver tissue interstitial microenvironment during liver cancer radiotherapy.

Radiation research - 1 Dec 2014

Zhi-Feng Wu, Le-Yuan Zhou, Xiao-Hui Zhou, Ya-Bo Gao, Jian-Ying Zhang, Yong Hu, Zhao-Chong Zeng

Abstract excerpt

Liver tissue interstitial fluid (TIF) a special microenvironment around liver cells, which may play a vital role in cell communication during liver injury. Moreover, toll-like receptor 4 (TLR4) is an important trigger of the immune response that may also play a role in liver injuries, including radiation-induced liver disease (RILD). Therefore, the purpose of this study was to identify the roles of the...

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Source

Identifiers

PMID: 25402554
DOI: 10.1667/RR13630.1

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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