Article
Cytoskeletal Alterations and Biomechanical Properties of parkin-Mutant Human Primary Fibroblasts.
Cell biochemistry and biophysics - 1 Apr 2015
Vergara Daniele, Ferraro Marzia M, Cascione Mariafrancesca, del Mercato Loretta L, Leporatti Stefano, Ferretta Anna, Tanzarella Paola, Pacelli Consiglia, Santino Angelo, Maffia Michele, Cocco Tiziana, Rinaldi Ross, Gaballo Antonio
Abstract excerpt
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Genes which have been implicated in autosomal-recessive PD include PARK2 which codes for parkin, an E3 ubiquitin ligase that participates in a variety of cellular activities. In this study, we compared parkin-mutant pr...
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