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Article

Chlamydia infection depends on a functional MDM2-p53 axis

13 Nov 2014

Abstract excerpt

Chlamydia, a major human bacterial pathogen, assumes effective strategies to protect infected cells against death-inducing stimuli, thereby ensuring completion of its developmental cycle. Paired with its capacity to cause extensive host DNA damage, this poses a potential risk of malignant transformation, consistent with circumstantial epidemiological evidence. Here we reveal a dramatic depletion of p53, a tumor...

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PMID: 25392082
DOI: 10.1038/ncomms6201

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