Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TLR2 promoter hypermethylation creates innate immune dysbiosis.

Journal of dental research - 1 Jan 2015

Benakanakere M, Abdolhosseini M, Hosur K, Finoti L S, Kinane D F

Abstract excerpt

Periodontitis is a common chronic inflammatory disease that is initiated by a complex microbial biofilm that poses significant health and financial burdens globally. Porphyromonas gingivalis is a predominant pathogen that maintains chronic inflammatory periodontitis. Toll-like receptors (TLRs) play an important role in periodontitis by recognizing pathogens and maintaining tissue homeostasis. Deficiencies in TLR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Bacteroidaceae Infections
Share to Chronic Periodontitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decitabine

Share to DNA Modification Methylases

Share to Dysbiosis

Share to Gingiva

Share to Porphyromonas gingivalis

Source

Open in PubMed Open full text

Identifiers

PMID: 25389002
DOI: 10.1177/0022034514557545
PMCID: PMC4270813

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLR2 promoter hypermethylation creates innate immune dysbiosis.PMID 25389002Read ↗

Epigenetic regulation of inflammation in localized aggressive periodontitisSemantic proximity Read ↗

The role of genome-wide DNA methylation and polymorphisms in periodontitis etiology: A narrative review.Semantic proximity Read ↗

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesisSemantic proximity Read ↗

Histone Methylation Mechanisms Modulate the Inflammatory Response of Periodontal Ligament ProgenitorsSemantic proximity Read ↗

Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis.Semantic proximity Read ↗

Current Concepts of Epigenetics and Its Role in PeriodontitisSemantic proximity Read ↗

Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetesSemantic proximity Read ↗

Modifiable risk factors in periodontal diseaseSemantic proximity Read ↗

Periodontal inflammation: Integrating genes and dysbiosisSemantic proximity Read ↗

The Relevance of DNA Methylation and Histone Modification in Periodontitis: A Scoping ReviewSemantic proximity Read ↗

DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalisSemantic proximity Read ↗

Alteration of <i>PTGS2</i> Promoter Methylation in Chronic PeriodontitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.