Article
Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis.
Journal of clinical periodontology - 1 Nov 2010
Zhang Shaoping, Crivello Antonino, Offenbacher Steven, Moretti Antonio, Paquette David W, Barros Silvana P
Abstract excerpt
AIM: The goal of this investigation was to determine whether epigenetic modifications in the IFNG promoter are associated with an increase of IFNG transcription in different stages of periodontal diseases. MATERIALS AND METHODS: DNA was extracted from gingival biopsy samples collected from 47 total sites from 47 different subjects: 23 periodontally healthy sites, 12 experimentally induced gingivitis sites and 12...
Topics
- Adult
- Analysis of Variance
- Case-Control Studies
- Chi-Square Distribution
- Chronic Periodontitis
- CpG Islands
- DNA Methylation
- Female
- Fluorescent Antibody Technique
- Gene Expression Regulation
- Gingivitis
- Humans
- Interferon-gamma