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Article

Sample processing obscures cancer-specific alterations in leukemic transcriptomes

10 Nov 2014

Abstract excerpt

Substantial effort is currently devoted to identifying cancer-associated alterations using genomics. Here, we show that standard blood collection procedures rapidly change the transcriptional and posttranscriptional landscapes of hematopoietic cells, resulting in biased activation of specific biological pathways; up-regulation of pseudogenes, antisense RNAs, and unannotated coding isoforms; and RNA surveillance...

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Share to Single-cell and spatial transcriptomics
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Identifiers

PMID: 25385641
DOI: 10.1073/pnas.1413374111

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