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Regulation of Coagulation Factor XI Expression by MicroRNAs in the Human Liver

7 Nov 2014

Abstract excerpt

High levels of factor XI (FXI) increase the risk of thromboembolic disease. However, the genetic and environmental factors regulating FXI expression are still largely unknown. The aim of our study was to evaluate the regulation of FXI by microRNAs (miRNAs) in the human liver. In silico prediction yielded four miRNA candidates that might regulate FXI expression. HepG2 cells were transfected with miR-181a-5p,...

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PMID: 25379760
DOI: 10.1371/journal.pone.0111713

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