Article
Identification of coagulation gene 3'UTR variants that are potentially regulated by microRNAs.
British journal of haematology - 1 Jun 2017
Vossen Carla Y, van Hylckama Vlieg Astrid, Teruel-Montoya Raúl, Salloum-Asfar Salam, de Haan Hugoline, Corral Javier, Reitsma Pieter, Koeleman Bobby P C, Martínez Constantino
Abstract excerpt
MicroRNAs have been recognized as critical regulators of gene expression and might affect the risk of venous thrombosis. We aimed to identify 3' untranslated region (UTR) variants in coagulation genes that influence coagulation factor levels and venous thrombosis risk. The 3'UTR of coagulation genes were sequenced in subjects with extremely high or low plasma levels of these factors in two case-control studies....
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