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Article

Osteocalcin and the pituitary-gonadal axis in older men: a population-based study.

Clinical endocrinology - 1 May 2015

Limonard E J, van Schoor N M, de Jongh R T, Lips P, Fliers E, Bisschop P H

Abstract excerpt

OBJECTIVE: Osteocalcin is a well-known marker of bone formation. Recently, mice lacking osteocalcin or its receptor were reported to be subfertile with low testosterone and high luteinizing hormone concentrations. In parallel, in humans, a loss-of-function mutation of the osteocalcin receptor was associated with hypergonadotropic hypogonadism. This suggests that osteocalcin is necessary for normal...

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PMID: 25376262
DOI: 10.1111/cen.12660

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