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Comparative Genomics of <i>Pneumocystis</i> Species Suggests the Absence of Genes for <i>myo-</i> Inositol Synthesis and Reliance on Inositol Transport and Metabolism

5 Nov 2014

Abstract excerpt

UNLABELLED: In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe). The underrepresentation of amino acid metabolism pathways compared to those in S. pombe, as...

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PMID: 25370490
DOI: 10.1128/mbio.01834-14

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