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Article

Excess cholesterol induces mouse egg activation and may cause female infertility

3 Nov 2014

Abstract excerpt

The HDL receptor scavenger receptor, class B type I (SR-BI) controls the structure and fate of plasma HDL. Female SR-BI KO mice are infertile, apparently because of their abnormal cholesterol-enriched HDL particles. We examined the growth and meiotic progression of SR-BI KO oocytes and found that they underwent normal germinal vesicle breakdown; however, SR-BI KO eggs, which had accumulated excess cholesterol in...

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PMID: 25368174
DOI: 10.1073/pnas.1418954111

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