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Article

CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes

5 Jul 2018

Abstract excerpt

BACKGROUND: In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to various ovarian diseases, such as premature ovarian insufficiency (POI). Although recent studies have revealed that several functional genes and pathways, such as phosphoinositide 3-kinase (PI3K)...

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PMID: 29976179
DOI: 10.1186/s12915-018-0541-4

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