Article
Detection of single-nucleotide polymorphisms in Plasmodium falciparum by PCR primer extension and lateral flow immunoassay.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Moers A P H A, Hallett R L, Burrow R, Schallig H D F H, Sutherland C J, van Amerongen A
Abstract excerpt
The resistance of Plasmodium falciparum to some antimalarial drugs is linked to single-nucleotide polymorphisms (SNPs). Currently, there are no methods for the identification of resistant parasites that are sufficiently simple, cheap, and fast enough to be performed at point-of-care, i.e., in local hospitals where drugs are prescribed. Primer extension methods (PEXT) were developed to identify 4 SNPs in P....
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