Article
Simple detection of single nucleotide polymorphism in Plasmodium falciparum by SNP-LAMP assay combined with lateral flow dipstick.
Parasitology international - 1 Feb 2017
Yongkiettrakul Suganya, Kampeera Jantana, Chareanchim Wanwisa, Rattanajak Roonglawan, Pornthanakasem Wichai, Kiatpathomchai Wansika, Kongkasuriyachai Darin
Abstract excerpt
The significant strides made in reducing global malaria burden over the past decades are being threatened by the emergence of multi-drug resistant malaria. Mechanisms of resistance to several classes of antimalarial drugs have been linked to key mutations in the Plasmodium falciparum genes. Pyrimethamine targets the dihydrofolate reductase of the bifunctional dihydrofolate reductase thymidylate synthase...
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