Article
Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant.
PloS one - 1 Jan 2014
Brennan Christopher M, Mazzucca Nicholas Q, Mezoian Taylor, Hunt Taylor M, Keane Meaghan L, Leonard Jessica N, Scola Shelby E, Beer Emma N, Perdue Sarah, Pellock Brett J
Abstract excerpt
The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing bacterium Shewanella oneidensis strain MR-1 results in slow exponential phase growth and a reduced terminal cell density at stationary phase. We have found that the exponential phase growth defect of the hfq mutant in LB is the result of reduced heme levels. Both...
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