Loss of OxyR reduces efficacy of oxygen respiration in Shewanella oneidensis.

Abstract excerpt

In many bacteria, OxyR is the major regulator controlling cellular response to H2O2. A common phenotype resulting from OxyR loss is reduced growth rate, but the underlying mechanism is unknown. We demonstrated in Shewanella oneidensis, an important research model for applied and environmental microbes, that the defect is primarily due to an electron shortage to major terminal oxidase cytochrome cbb3. The loss of...

Topics

• Electron Transport Complex IV
• Gene Expression Regulation, Bacterial
• Microbial Viability
• Mutation
• NAD
• Operon
• Oxidative Stress
• Oxygen
• Oxygen Consumption
• Shewanella
• Trans-Activators