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Article

Argonaute proteins affect siRNA levels and accumulation of a novel extrachromosomal DNA from the Dictyostelium retrotransposon DIRS-1.

The Journal of biological chemistry - 19 Dec 2014

Boesler Benjamin, Meier Doreen, Förstner Konrad U, Friedrich Michael, Hammann Christian, Sharma Cynthia M, Nellen Wolfgang

Abstract excerpt

The retrotransposon DIRS-1 is the most abundant retroelement in Dictyostelium discoideum and constitutes the pericentromeric heterochromatin of the six chromosomes in D. discoideum. The vast majority of cellular siRNAs is derived from DIRS-1, suggesting that the element is controlled by RNAi-related mechanisms. We investigated the role of two of the five Argonaute proteins of D. discoideum, AgnA and AgnB, in...

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Identifiers

PMID: 25352599
DOI: 10.1074/jbc.M114.612663
PMCID: PMC4271202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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