Article
Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling.
Molecular medicine reports - 1 Feb 2015
Ito Takuji, Bai Tao, Tanaka Tetsuji, Yoshida Kenji, Ueyama Takashi, Miyajima Masayasu, Negishi Takayuki, Kawasaki Takahiko, Takamatsu Hyota, Kikutani Hitoshi, Kumanogoh Atsushi, Yukawa Kazunori
Abstract excerpt
The opening of the mouse vaginal cavity to the skin is a postnatal tissue remodeling process that occurs at approximately five weeks of age for the completion of female genital tract maturation at puberty. The tissue remodeling process is primarily composed of a hormonally triggered apoptotic process predominantly occurring in the epithelium of the distal section of the vaginal cavity. However, the detailed...
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