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Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

16 Nov 2006

Abstract excerpt

During germ-cell migration in the mouse, the dynamics of embryo growth cause many germ cells to be left outside the range of chemoattractive signals from the gonad. At E10.5, movie analysis has shown that germ cells remaining in the midline no longer migrate directionally towards the genital ridges, but instead rapidly fragment and disappear. Extragonadal germ cell tumors of infancy, one of the most common...

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PMID: 17107997
DOI: 10.1242/dev.02688

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