Article
Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA.
PloS one - 1 Jan 2014
Hill Aubrey E, Plyler Zackery E, Tiwari Hemant, Patki Amit, Tully Joel P, McAtee Christopher W, Moseley Leah A, Sorscher Eric J
Abstract excerpt
Like many other ancient genes, the cystic fibrosis transmembrane conductance regulator (CFTR) has survived for hundreds of millions of years. In this report, we consider whether such prodigious longevity of an individual gene--as opposed to an entire genome or species--should be considered surprising in the face of eons of relentless DNA replication errors, mutagenesis, and other causes of sequence polymorphism....
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