Why so many noncoding nucleotides? The eukaryote genome as an epigenetic machine.

doi:10.1023/a:1016080316076

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Article

Why so many noncoding nucleotides? The eukaryote genome as an epigenetic machine.

Genetica - 1 May 2002

Zuckerkandl Emile

Abstract excerpt

It is recalled that dispensability of sequences and neutral substitution rate must not be construed to be markers of nonfunctionality. Different aspects of functionality relate to differently-sized nucleotide communities. At the time cells became nucleated, a boom of epigenetic processes led to uses of DNA that required many more nucleotides operating collectively than do functions definable in terms of classical...

Topics

DNA, Intergenic
Enhancer Elements, Genetic
Eukaryotic Cells
Gene Expression Regulation
Genome
Introns
Mutation
Promoter Regions, Genetic
Selection, Genetic
Short Interspersed Nucleotide Elements

Source

Open in PubMed

Identifiers

PMID: 12188043
DOI: 10.1023/a:1016080316076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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