Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Automated liquid culture system misses isoniazid heteroresistance in Mycobacterium tuberculosis isolates with mutations in the promoter region of the inhA gene.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Mar 2015

Zhang Z, Lu J, Wang Y, Pang Y, Zhao Y

Abstract excerpt

Heteroresistance in Mycobacterium tuberculosis isolates remains the major challenge for phenotypic drug susceptibility testing (DST) methods to detect drug resistance. The aim of this study was to investigate the abilities of phenotypic DST methods to identify the isoniazid (INH) heteroresistance in M. tuberculosis. We found that the broth dilution method was able to detect INH resistance if 0.5 % resistant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Automation, Laboratory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to False Negative Reactions

Share to Isoniazid

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Oxidoreductases

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 25344830
DOI: 10.1007/s10096-014-2262-0

Genes

DST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Automated liquid culture system misses isoniazid heteroresistance in Mycobacterium tuberculosis isolates with mutations in the promoter region of the inhA gene.PMID 25344830Read ↗

Co-resistance to isoniazid and second-line anti-tuberculosis drugs in isoniazid-resistant tuberculosis at a tertiary care hospital in Thailand.Semantic proximity Read ↗

Genotypic and phenotypic drug-resistance detection and prevalence of heteroresistance in patients with isoniazid- and multidrug-resistant tuberculosis in EthiopiaSemantic proximity Read ↗

Heteroresistance to rifampicin & isoniazid in clinical samples of patients with presumptive drug-resistant tuberculosis in Central India.Semantic proximity Read ↗

Prevalence and resistance spectrum of ahpC mutations in isoniazid-resistant Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USASemantic proximity Read ↗

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Highly Sensitive Detection of Isoniazid Heteroresistance in Mycobacterium Tuberculosis by Droplet Digital PCRSemantic proximity Read ↗

Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Rifampin Resistance Missed in Automated Liquid Culture System for Mycobacterium tuberculosis Isolates with Specific <i>rpoB</i> MutationsSemantic proximity Read ↗

Analysis of discrepant results between the Genotype® MTBDRplus assay and an antimicrobial drug susceptibility test for isoniazid-resistant tuberculosis.Semantic proximity Read ↗

Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China.Semantic proximity Read ↗

[Heteroresistance in Mycobacteria tuberculosis is an important factor for the inconsistency between the results of phenotype and genotype drug susceptibility tests].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.