Article
The extracellular heme-binding protein HbpS from the soil bacterium Streptomyces reticuli is an aquo-cobalamin binder.
The Journal of biological chemistry - 5 Dec 2014
Ortiz de Orué Lucana Darío, Fedosov Sergey N, Wedderhoff Ina, Che Edith N, Torda Andrew E
Abstract excerpt
The extracellular protein HbpS from Streptomyces reticuli interacts with iron ions and heme. It also acts in concert with the two-component sensing system SenS-SenR in response to oxidative stress. Sequence comparisons suggested that the protein may bind a cobalamin. UV-visible spectroscopy confirmed binding (Kd = 34 μm) to aquo-cobalamin (H2OCbl(+)) but not to other cobalamins. Competition experiments with the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.