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Article

Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis.

Scientific reports - 20 Jan 2015

Jiang Benchun, Zhu Ke, Shao Hua, Bao Chenhui, Ou Jinlei, Sun Wei

Abstract excerpt

E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in increased susceptibility to tumor development and subsequent tumor cell invasion and metastasis. The CDH1 C-160A polymorphism could decrease its transcription efficiency and may increase...

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Topics

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Share to Antigens, CD
Share to Cadherins
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Stomach Neoplasms

Source

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Identifiers

PMID: 25599647
DOI: 10.1038/srep07891
PMCID: PMC4298742

Genes

CDH1

Provenance

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