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Article

MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming

21 Oct 2014

Abstract excerpt

Somatic cells can be reprogrammed to reach an embryonic stem cell-like state by overexpression of defined factors. Recent studies have greatly improved the efficiency of the reprogramming process but the underlying mechanisms regulating the transition from a somatic to a pluripotent state are still relatively unknown. MicroRNAs (miRs) are small noncoding RNAs that primarily regulate target gene expression...

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PMID: 25336587
DOI: 10.1261/rna.043745.113

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