Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects

12 Jun 2014

Abstract excerpt

BACKGROUND: Schistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives. Studies on protein kinases (PKs) demonstrated their importance for diverse physiological processes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Macrophage Migration Inhibitory Factor
Share to Parasites and Host Interactions
Share to Research on Leishmaniasis Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24921634
DOI: 10.1371/journal.pntd.0002923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic EffectsPMID 24921634Read ↗

Schistosomes alter expression of immunomodulatory gene products following <i>in vivo</i> praziquantel exposureSemantic proximity Read ↗

The Transcriptome of Schistosoma mansoni Developing Eggs Reveals Key Mediators in Pathogenesis and Life Cycle PropagationSemantic proximity Read ↗

Protein Kinases as Potential Targets for Novel Anti-Schistosomal StrategiesSemantic proximity Read ↗

Re-Positioning Protein-Kinase Inhibitors Against SchistosomiasisSemantic proximity Read ↗

Developmental gene expression profiles of the human pathogen Schistosoma japonicumSemantic proximity Read ↗

Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targetsSemantic proximity Read ↗

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite <i>Schistosoma mansoni</i>Semantic proximity Read ↗

Artemisitene protected against murine schistosomiasis japonica through anti-parasite activity and immune regulationSemantic proximity Read ↗

The transcriptome of <i>Schistosoma mansoni</i> developing eggs reveals key mediators in pathogenesis and life cycle propagationSemantic proximity Read ↗

RNAi screening of uncharacterized genes identifies promising druggable targets in Schistosoma japonicumSemantic proximity Read ↗

Calmodulin disruption impacts growth and motility in juvenile liver fluke.Semantic proximity Read ↗

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.