Article
Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population.
Tissue antigens - 1 Nov 2014
Lindenau J D, Guimarães L S P, Hurtado A M, Hill K R, Tsuneto L T, Salzano F M, Petzl-Erler M L, Hutz M H
Abstract excerpt
The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still...
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