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Article

[Generation of induced pluripotent stem cells from amyotrophic lateral sclerosis patientcarrying SOD1-V14M mutation].

Zhonghua yi xue za zhi - 15 Jul 2014

Liu Xinxiu, Chen Jiayu, Li Xiaogang, Gao Shaorong, Deng Min

Abstract excerpt

OBJECTIVE: To generate familial ALS patient specific induced pluripotent stem (iPS) cell lines and motor neurons and provide a cell-based disease model for amyotrophic lateral sclerosis (ALS) in Han Chinese. METHODS: iPS cells were derived from familial ALS patient by introducing 4 transcription factors OCT3/4, SOX2, KLF4 and c-MYC into fibroblast cells by retroviruses. Karyotypic analysis, immunofluorescence...

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Source

Identifiers

PMID: 25327864

Genes

SOD1
KLF4
MYC
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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