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Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein

16 Oct 2014

Abstract excerpt

BACKGROUND: Plants remain an important source of new drugs, new leads and new chemical entities. Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii Hook F that possesses a broad range of bioactivities, including anti-inflammatory, immunosuppressive and anti-tumor properties. The antiviral activity of triptolide against human immunodeficiency virus type 1 (HIV-1) has not been reported....

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PMID: 25323821
DOI: 10.1186/s12977-014-0088-6

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