Article
Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014
Mitani Yoshitsugu, Rao Pulivarthi H, Maity Sankar N, Lee Yu-Chen, Ferrarotto Renata, Post Julian C, Licitra Lisa, Lippman Scott M, Kies Merrill S, Weber Randal S, Caulin Carlos, Lin Sue-Hwa, El-Naggar Adel K
Abstract excerpt
PURPOSE: To investigate the molecular events associated with the activation of androgen receptor (AR) as a potential therapeutic target in patients with salivary duct carcinoma (SDC). EXPERIMENTAL DESIGN: Comprehensive molecular and expression analysis of the AR gene in 35 tumor specimens (20 males and 15 females) and cell lines derived from SDC using Western blotting and RT-PCR, FISH analysis, and DNA sequencing...
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