Article
Blockade of Androgen-induced Malignant Phenotypes by Flutamide Administration in Human Salivary Duct Carcinoma Cells.
Anticancer research - 1 Nov 2016
Kamata Y U, Sumida Tomoki, Murase Ryuichi, Nakano Hiroyuki, Yamada Tomohiro, Mori Yoshihide
Abstract excerpt
BACKGROUND/AIM: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen...
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