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Article

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

13 Oct 2014

Abstract excerpt

We sought to determine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscle through hypothesis generation using muscle profiling data (human dystrophy and murine regeneration). We found that transforming growth factor β-centered networks strongly associated with pathological fibrosis and failed regeneration were also induced during normal regeneration but at distinct time...

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PMID: 25313409
DOI: 10.1083/jcb.201402079

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