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Article

Multiplex SNP detection in multiple codons for accurate drug therapy.

Chemical communications (Cambridge, England) - 4 Dec 2014

Sayyed Danishmalik Rafiq, Nimse Satish Balasaheb, Song Keum-Soo, Sung Nackmoon, Kim Taisun

Abstract excerpt

Multiplex SNP discrimination in the multiple codons of the genomic DNA is demonstrated by applying controller DNA technology (CDT) to MDR-TB 9G DNAChips. CDT allowed the efficient detection of 20 SNPs in five codons of the genomic DNA in 40 min. CDT could distinguish SNP targets to as low as 1 copy of the genomic DNA. 100% agreement with the sequencing analysis of clinical samples highlighted the clinical...

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PMID: 25307892
DOI: 10.1039/c4cc06625a

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