Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

doi:10.1002/art.38912

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Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2015

Yokoyama Koji, Ikeya Makoto, Umeda Katsutsugu, Oda Hirotsugu, Nodomi Seishiro, Nasu Akira, Matsumoto Yoshihisa, Izawa Kazushi, Horigome Kazuhiko, Kusaka Toshimasa, Tanaka Takayuki, Saito Megumu K, Yasumi Takahiro, Nishikomori Ryuta, Ohara Osamu, Nakayama Naoki, Nakahata Tatsutoshi, Heike Toshio, Toguchida Junya

Abstract excerpt

OBJECTIVE: Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore occur independently of the NLRP3 inflammasome. This study was undertaken to...

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PMID: 25302486
DOI: 10.1002/art.38912

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NLRP3
SOX9

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