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Article

Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias.

Stem cell reports - 9 Mar 2021

Pretemer Yann, Kawai Shunsuke, Nagata Sanae, Nishio Megumi, Watanabe Makoto, Tamaki Sakura, Alev Cantas, Yamanaka Yoshihiro, Xue Jing-Yi, Wang Zheng, Fukiage Kenichi, Tsukanaka Masako, Futami Tohru, Ikegawa Shiro, Toguchida Junya

Abstract excerpt

Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system has been reported to analyze the pathology in humans. Here, we developed a three-dimensional culture protocol to differentiate hypertrophic chondrocytes from induced pluripotent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33636111
DOI: 10.1016/j.stemcr.2021.01.014
PMCID: PMC7940258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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