Article
Suitability of small bronchoscopic tumour specimens for lung cancer genotyping.
Respiration; international review of thoracic diseases - 1 Jan 2014
Dooms Christophe, Vliegen Liesbet, Vander Borght Sara, Yserbyt Jonas, Hantson Inge, Verbeken Eric, Wauters Els, Nackaerts Kristiaan, Ninane Vincent, Vansteenkiste Johan, Vandenberghe Peter
Abstract excerpt
BACKGROUND: Biomarker-driven clinical trials in advanced non-small cell lung cancer (NSCLC) usually accept biopsy specimens only, as cytology specimens are supposed to be more challenging due to low neoplastic cell content and suboptimal DNA quantity. OBJECTIVES: We aimed to evaluate 2 aspects of bronchoscopic biopsy and cytology specimens: (1) the proportion of neoplastic cells and quantity of DNA extracted, and...
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