Article
The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53.
BioMed research international - 1 Jan 2013
Shin Soyeon, Jing Kaipeng, Jeong Soyeon, Kim Nayeong, Song Kyoung-Sub, Heo Jun-Young, Park Ji-Hoon, Seo Kang-Sik, Han Jeongsu, Park Jong-Il, Kweon Gi-Ryang, Park Seung-Kiel, Wu Tong, Hwang Byung-Doo, Lim Kyu
Abstract excerpt
Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study investigated the effects of DHA on PC3 and DU145 prostate cancer cell lines harboring mutant p53. Results show that, in addition to apoptosis, DHA increased the expression levels of lipidated form LC3B and potently stimulated the autophagic flux, suggesting that DHA...
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