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Article

Insights into the inhibitory mechanisms of the regulatory protein IIA(Glc) on melibiose permease activity.

The Journal of biological chemistry - 21 Nov 2014

Hariharan Parameswaran, Guan Lan

Abstract excerpt

The phosphotransfer protein IIA(Glc) of the bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system plays a key role in the regulation of carbohydrate metabolism. Melibiose permease (MelB) is one among several permeases subject to IIA(Glc) regulation. The regulatory mechanisms are poorly understood; in addition, thermodynamic features of IIA(Glc) binding to other proteins are also unknown. Applying...

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Identifiers

PMID: 25296751
DOI: 10.1074/jbc.M114.609255
PMCID: PMC4239646

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