Article
[Gliomas and BRCA genes mutations: fortuitous association or imputability?].
Bulletin du cancer - 1 Sept 2014
Girardstein-Boccara Laura, Mari Véronique, Met-Domestici Marie, Burel-Vandenbos Fanny, Berthet Pascaline, Paquis Philippe, Frenay Marc Paul, Lebrun-Frenay Christine
Abstract excerpt
BRCA is a tumor suppressor gene implicated in the major mechanisms of cellular stability in every type of cell. Its mutations are described in numerous cancers, mainly breast and ovarian in women. It was also found an increase of lifetime risk of pancreas, colon, prostate cancer or lymphoma in men carriers. We report the cases of two female patients aged 40 and 58-years-old female patients and one 35-years-old...
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