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Article

Role of a remote leucine residue in the catalytic function of polyol dehydrogenase.

Molecular bioSystems - 1 Dec 2014

Tiwari Manish Kumar, Kalia Vipin C, Kang Yun Chan, Lee Jung-Kul

Abstract excerpt

Studies on the protein-metal binding sites have mainly focused on the residues immediately surrounding the reacting substrate, cofactors, and metal ions. The contribution of residues in remote layers to the highly optimized microenvironments of catalytic active sites is not well understood. To improve our understanding, the present study examined the role of remote residues on the structure and function of...

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PMID: 25292207
DOI: 10.1039/c4mb00459k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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