Article
Distinct conformation-mediated functions of an active site loop in the catalytic reactions of NAD-dependent D-lactate dehydrogenase and formate dehydrogenase.
The Journal of biological chemistry - 29 Apr 2005
Shinoda Takeshi, Arai Kazuhito, Shigematsu-Iida Mayu, Ishikura Yoshirou, Tanaka Satoru, Yamada Takashi, Kimber Matthew S, Pai Emil F, Fushinobu Shinya, Taguchi Hayao
Abstract excerpt
The three-dimensional structures of NAD-dependent D-lactate dehydrogenase (D-LDH) and formate dehydrogenase (FDH), which resemble each other, imply that the two enzymes commonly employ certain main chain atoms, which are located on corresponding loop structures in the active sites of the two enzymes, for their respective catalytic functions. These active site loops adopt different conformations in the two...
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