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Article

Abnormal methylation of the sex-determining region Y-box 17 (SOX17) promoter predicts poor prognosis in myelodysplastic syndrome.

Clinical laboratory - 1 Jan 2014

Fan Rong, Zhao Xiao-Li, Wang Hong, He Hai-Yan, Peng Zhen-Ping, Yang Bo, Han Tao, Wang Wei, Wang Xiao-Qin, Lin Guo-Wei

Abstract excerpt

BACKGROUND: The sex-determining region Y-box 17 (SOX17) is a member of the high mobility group (HMG) transcription factor family, which plays critical roles in the regulation of development and stem/precursor cell function. Recent evidence demonstrated that SOX17 acts as a tumor-suppressor gene, at least partly though repression of Wnt pathway activity. METHODS: Here we report that SOX17 methylation was detected...

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Source

Identifiers

PMID: 25291942
DOI: 10.7754/clin.lab.2013.130414

Genes

SOX17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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