Article
Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Robinson Elise B, Samocha Kaitlin E, Kosmicki Jack A, McGrath Lauren, Neale Benjamin M, Perlis Roy H, Daly Mark J
Abstract excerpt
Autism spectrum disorders (ASDs) are a highly heterogeneous group of conditions--phenotypically and genetically--although the link between phenotypic variation and differences in genetic architecture is unclear. This study aimed to determine whether differences in cognitive impairment and symptom severity reflect variation in the degree to which ASD cases reflect de novo or familial influences. Using data from...
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