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Article

The role of de novo mutations in the genetics of autism spectrum disorders.

Nature reviews. Genetics - 1 Feb 2014

Ronemus Michael, Iossifov Ivan, Levy Dan, Wigler Michael

Abstract excerpt

The identification of the genetic components of autism spectrum disorders (ASDs) has advanced rapidly in recent years, particularly with the demonstration of de novo mutations as an important source of causality. We review these developments in light of genetic models for ASDs. We consider the number of genetic loci that underlie ASDs and the relative contributions from different mutational classes, and we...

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PMID: 24430941
DOI: 10.1038/nrg3585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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