Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type.

Human pathology - 1 Dec 2014

Nomura Ryosuke, Saito Tsuyoshi, Mitomi Hiroyuki, Hidaka Yasuhiro, Lee Se-yong, Watanabe Sumio, Yao Takashi

Abstract excerpt

Gastric adenocarcinoma of the fundic gland type (GAFG) is a rare variant of gastric tumor. We have recently reported the frequent accumulation of β-catenin in GAFGs and showed that approximately half of the cases studied harbored at least 1 mutation in CTNNB1/AXINs/APC, leading to the constitutive activation of the Wnt/β-catenin pathway. However, the mechanisms of Wnt signaling activation in the remaining cases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromogranins

Share to Gastric Mucosa

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Immunohistochemistry

Share to Stomach Neoplasms

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 25288233
DOI: 10.1016/j.humpath.2014.08.016

Genes

GNAS
APC
CTNNB1
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type.PMID 25288233Read ↗

Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps.Semantic proximity Read ↗

Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type.Semantic proximity Read ↗

Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum.Semantic proximity Read ↗

Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma.Semantic proximity Read ↗

Mutational Landscape of Gastric Adenocarcinoma of the Fundic Gland Type Revealed by Whole Genome Sequencing.Semantic proximity Read ↗

Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland typeSemantic proximity Read ↗

Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene.Semantic proximity Read ↗

Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma.Semantic proximity Read ↗

Activating KRAS and GNAS mutations in heterotopic submucosal glands of the stomach.Semantic proximity Read ↗

Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations.Semantic proximity Read ↗

Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis.Semantic proximity Read ↗

Oncogene addiction to GNAS in GNASR201 mutant tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.