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Article

microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity.

Molecular cancer - 6 Oct 2014

Martin Elizabeth C, Rhodes Lyndsay V, Elliott Steven, Krebs Adrienne E, Nephew Kenneth P, Flemington Erik K, Collins-Burow Bridgette M, Burow Matthew E

Abstract excerpt

BACKGROUND: The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer. METHODS AND RESULTS: Here we use deep sequencing analysis of previously published data from The Cancer Genome Atlas to demonstrate that expression of a key component of mTOR signaling,...

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Source

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Identifiers

PMID: 25283550
DOI: 10.1186/1476-4598-13-229
PMCID: PMC4203920

Genes

TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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