Article
The role of functional polymorphisms of cyclooxygenase 2 in renal cell carcinoma.
Anticancer research - 1 Oct 2014
Chang Wen-Shin, Liao Cheng-Hsi, Miao Chia-En, Wu Hsi-Chin, Hou Lin-Lin, Hsiao Chieh-Lun, Ji Hong-Xue, Tsai Chia-Wen, Bau Da-Tian
Abstract excerpt
Renal cell carcinoma (RCC) accounts for about 3% of all cancer-related mortalities worldwide and the risk factors for the development of RCC have not yet been fully elucidated. Mounting evidence shows that overexpression of cyclo-oxygenase 2 (COX2) is commonly found in malignant tumors, including RCC. However, the contribution of genotypic variations of COX2 to RCC has not been studied. We hypothesized that...
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