Article
Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk.
Diabetologia - 1 Dec 2014
Klimentidis Yann C, Chen Zhao, Arora Amit, Hsu Chiu-Hsieh
Abstract excerpt
AIMS/HYPOTHESIS: We examined whether or not the association of physical activity with type 2 diabetes incidence differs according to several types of genetic susceptibility. METHODS: In a large prospective cohort with 821 incident cases of type 2 diabetes, we examined interactions of physical activity with: (1) each of 65 type 2 diabetes-associated single nucleotide polymorphisms (SNPs); (2) a genetic risk score...
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