Article
BRAF mutation status in primary and metastatic melanomas in two regions with differing potential ultraviolet radiation exposure.
Clinical and experimental dermatology - 1 Dec 2014
Massad C, Loya A, Taraif S, Saroufim M, Kibbi A G, Habib R, Novy M, Rauscher B, Oberkanins C, Khalifeh I
Abstract excerpt
BACKGROUND: Melanoma is seen as a heterogeneous molecular entity, with solar ultraviolet radiation (UVR) and BRAF mutation status being important determinants. AIM: To study primary and metastatic melanomas from two UVR-distinct regions to elucidate correlations between prognostic predictors, UVR and BRAF mutation status. METHODS: Extended BRAF testing for 9 mutations was obtained for 95 primary melanomas...
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